DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only
a fraction of their corresponding DNA sequence motifs in any given cell type. Chromatin has …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Fruit has evolved myriad forms that facilitate seed dispersal in varied environmental and
ecological contexts. Because fleshy fruits become attractive and nutritious to seed …