Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

The health burden of stress-related diseases, including depression and anxiety disorders, is
rapidly increasing, whereas the range of available pharmacotherapies to treat these …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Cholesterol influences many of the biophysical properties of membranes and is
nonrandomly distributed between cellular organelles, subdomains of membranes, and …

Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …