Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis

G Hajishengallis, PI Diaz - Current oral health reports, 2020 - Springer
Abstract Purpose of Review This review summarizes mechanisms by which Porphyromonas
gingivalis interacts with community members and the host so that it can persist in the …

Gram‐negative periodontal bacteria induce the activation of Toll‐like receptors 2 and 4, and cytokine production in human periodontal ligament cells

Y Sun, R Shu, CL Li, MZ Zhang - Journal of periodontology, 2010 - Wiley Online Library
Background: Periodontitis is a bacterially induced chronic inflammatory disease. Toll‐like
receptors (TLRs), which could recognize microbial pathogens, are important components in …

Innocent until proven guilty: mechanisms and roles of Streptococcus–Candida interactions in oral health and disease

H Xu, HF Jenkinson… - Molecular oral …, 2014 - Wiley Online Library
Candida albicans and streptococci of the mitis group colonize the oral cavities of the majority
of healthy humans. While C. albicans is considered an opportunistic pathogen, streptococci …

[HTML][HTML] Porphyromonas gingivalis stimulates bone resorption by enhancing RANKL (receptor activator of NF-κB ligand) through activation of toll-like receptor 2 in …

A Kassem, P Henning, P Lundberg, PPC Souza… - Journal of Biological …, 2015 - ASBMB
Periodontitis has been associated with rheumatoid arthritis. In experimental arthritis,
concomitant periodontitis caused by oral infection with Porphyromonas gingivalis enhances …

Complement and dysbiosis in periodontal disease

G Hajishengallis, JD Lambris - Immunobiology, 2012 - Elsevier
Signaling crosstalk between complement and Toll-like receptors (TLRs) normally serves to
coordinate host immunity. However, the periodontal bacterium Porphyromonas gingivalis …

[HTML][HTML] Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis

JT Marchesan, EA Gerow, R Schaff, AD Taut… - Arthritis research & …, 2013 - Springer
Introduction Clinical studies suggest a direct influence of periodontal disease (PD) on serum
inflammatory markers and disease assessment of patients with established rheumatoid …

Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and …

J Lin, L Bi, X Yu, T Kawai, MA Taubman… - Infection and …, 2014 - Am Soc Microbiol
Toll-like receptors (TLRs) play a key role in the innate immune responses to periodontal
pathogens in periodontal disease. The present study was performed to determine the roles …

The role of oral pathobionts in dysbiosis during periodontitis development

Y Jiao, M Hasegawa, N Inohara - Journal of dental research, 2014 - journals.sagepub.com
An emerging concept is the tight relationship between dysbiosis (microbiota imbalance) and
disease. The increase in knowledge about alterations in microbial communities that reside …

Serum-and glucocorticoid-inducible kinase 1 promotes alternative macrophage polarization and restrains inflammation through FoxO1 and STAT3 signaling

J Ren, X Han, H Lohner, R Liang, S Liang… - The Journal of …, 2021 - journals.aai.org
Expression and activity of serum-and glucocorticoid-inducible kinase 1 (SGK1) are
associated with many metabolic and inflammatory diseases. In this study, we report that …

[HTML][HTML] Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes

MR Benakanakere, Q Li, MA Eskan, AV Singh… - Journal of biological …, 2009 - ASBMB
Mammalian biological processes such as inflammation, involve regulation of hundreds of
genes controlling onset and termination. MicroRNAs (miRNAs) can translationally repress …