This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …

After spinal cord injury, the disruption of blood–spinal cord barrier by activation of matrix
metalloprotease is a critical event leading to infiltration of blood cells, inflammatory …

It is known that some antidepressants and antipsychotics directly inhibit NMDA-type
ionotropic glutamate receptors. In this study we systematically studied action of seven drugs …

Ischemia induces blood–brain barrier (BBB) disruption by matrix metalloproteases (MMPs)
activation, leading to neuronal cell death. Here, we show that fluoxetine inhibits apoptotic …

The contribution of oxidative stress has been described in numerous studies as one of the
main pathways involved in the pathophysiology of anxiety and its comorbidities, such as …

The treatment of bipolar depression is one of the most challenging issues in contemporary
psychiatry. Currently only quetiapine and the olanzapine–fluoxetine combination are …

Rationale An effective and safe treatment of insomnia in patients with neuropathic pain
remains an unmet need. Melatonin and its analogs have been shown to have both …

Diabetic neuropathy is one of the most common complications of diabetes mellitus. Excess
glutamate release and oxidative stress are hypothesized to be involved in the …

Objective: to study the probable site of antinociceptive action of SSRI (fluoxetine,
escitalopram) and atypical antidepressants (mirtazapine, venlafaxine) and their interaction …