Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide
due to a single infectious agent. Despite chemotherapy, the global tuberculosis epidemic …

Most antibiotics are produced by soil microbes and typically interfere with macromolecular
synthesis processes as their antibacterial mechanism of action. These natural products are …

The tuberculosis (TB) pandemic continues to rampage despite widespread use of the BCG
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …

Mutations in the leucine‐rich repeat kinase 2 (LRRK2) are associated with Parkinson's
disease, chronic inflammation and mycobacterial infections. Although there is evidence …

Rationale: Cigarette smoking is linked to important aspects of tuberculosis, such as
susceptibility to infection, disease reactivation, mortality, transmission, and persistent …

The spread of human immunodeficiency virus (HIV) infection within Africa led to marked
increases in numbers of cases of tuberculosis (TB), and although the epidemic peaked in …

We postulate that similar to bacteria, adult stem cells may also exhibit an altruistic defense
mechanism to protect their niche against external threat. Herein, we report mesenchymal …

Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent
and intense exposure. These persons do not exhibit adaptive immune priming as measured …