Structure and function of hepatobiliary ATP binding cassette transporters
The liver is beyond any doubt the most important metabolic organ of the human body. This
function requires an intensive crosstalk within liver cellular structures, but also with other …
function requires an intensive crosstalk within liver cellular structures, but also with other …
Approaches to minimize the effects of P‐glycoprotein in drug transport: A review
A Husain, V Makadia, GR Valicherla… - Drug development …, 2022 - Wiley Online Library
Abstract P‐glycoprotein (P‐gp) is a transporter protein that is come under the ATP binding
cassette family of proteins. It is situated on the surface of the intestine epithelium, where P …
cassette family of proteins. It is situated on the surface of the intestine epithelium, where P …
Risk for bleeding-related hospitalizations during use of amiodarone with apixaban or rivaroxaban in patients with atrial fibrillation: a retrospective cohort study
Background: Amiodarone, the most effective antiarrhythmic drug in atrial fibrillation, inhibits
apixaban and rivaroxaban elimination, thus possibly increasing anticoagulant-related risk …
apixaban and rivaroxaban elimination, thus possibly increasing anticoagulant-related risk …
Mechanisms and the clinical relevance of complex drug–drug interactions
AG Roberts, ME Gibbs - Clinical pharmacology: advances and …, 2018 - Taylor & Francis
As a result of an increasing aging population, the number of individuals taking multiple
medications simultaneously has grown considerably. For these individuals, taking multiple …
medications simultaneously has grown considerably. For these individuals, taking multiple …
[HTML][HTML] The alternating access mechanism in mammalian multidrug resistance transporters and their bacterial homologs
Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC)
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …
Drug interactions with antihypertensives
MA Fravel, M Ernst - Current hypertension reports, 2021 - Springer
Abstract Purpose of Review Hypertension is remarkably prevalent, affecting an estimated
1.13 billion people worldwide. It often requires the use of multi-drug regimens and is …
1.13 billion people worldwide. It often requires the use of multi-drug regimens and is …
Drug-drug interactions in prostate cancer treatment
D Hebenstreit, R Pichler, I Heidegger - Clinical genitourinary cancer, 2020 - Elsevier
Polypharmacy is associated with an increased risk of drug-drug interactions (DDIs), which
can cause serious and debilitating drug-induced adverse events. With a steadily aging …
can cause serious and debilitating drug-induced adverse events. With a steadily aging …
[HTML][HTML] Ion channel expression in human melanoma samples: in silico identification and experimental validation of molecular targets
D D'Arcangelo, F Scatozza, C Giampietri, P Marchetti… - Cancers, 2019 - mdpi.com
Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human
melanoma samples and controls. Ninety-one members of this gene-family (ie, about 28%) …
melanoma samples and controls. Ninety-one members of this gene-family (ie, about 28%) …
ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1
MR Arana, GA Altenberg - Current medicinal chemistry, 2019 - ingentaconnect.com
Background: Proteins that belong to the ATP-binding cassette superfamily include
transporters that mediate the efflux of substrates from cells. Among these exporters, P …
transporters that mediate the efflux of substrates from cells. Among these exporters, P …
The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated by atomic force microscopy
The membrane-bound P-glycoprotein (Pgp) transporter plays a major role in human disease
and drug disposition because of its ability to efflux a chemically diverse range of drugs …
and drug disposition because of its ability to efflux a chemically diverse range of drugs …