Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular
functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Cadmium (Cd) is a persistent environmental and occupational contaminant that
accumulates in the liver and induces oxidative stress and inflammation. Melatonin …

The mycotoxin ochratoxin A (OTA) is a widespread contaminant in human and animal food
products. Previous studies in rats revealed that melatonin (Mel) exhibits a preventive effect …

Editor's Note: As an acute condition quickly associated with multiple chronic susceptibilities,
COVID-19 has rekindled interest in, and controversy about, the potential role of the host in …

This review summarizes published reports on the utility of melatonin as a treatment for virus-
mediated diseases. Of special note are the data related to the role of melatonin in …