In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …

Currently, radiation therapy is one of the standard therapies for cancer treatment. Since the
first applications, the field of radiotherapy has constantly improved, both in imaging …

Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches
that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been …

Although there is no shortage of potential targets for cancer therapeutics, we know of only a
handful of molecules that are differentially expressed in cancer and intersect multiple …

In the continuing search for effective treatments for cancer, the emerging model is the
combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood …

New data indicate that primary dysfunction in the tumour microenvironment, in addition to
epithelial dysfunction, can be crucial for carcinogenesis. These recent findings make a …

Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted
attention from several viewpoints of basic and translational research. Its cell cycle-regulated …

Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell
specific growth factor stimulating angiogenesis and vascular permeability. Some family …

Nanoscale drug delivery vehicles can facilitate multimodal therapies of cancer by promoting
tumour-selective drug release. However, few are effective because cancer cells develop …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …