1, 2, 3‐Triazole hybrids as anticancer agents: A review

MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …

Research progress on the synthesis and pharmacology of 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole derivatives: a mini review

JJ Wang, W Sun, WD Jia, M Bian… - Journal of Enzyme …, 2022 - Taylor & Francis
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …

Mechanistic Wound Healing and Antioxidant Potential of Moringa oleifera Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular …

NH Shady, NM Mostafa, S Fayez, IM Abdel-Rahman… - Antioxidants, 2022 - mdpi.com
Moringa oleifera Lam.(Moringaceae) is an adaptable plant with promising phytoconstituents,
interesting medicinal uses, and nutritional importance. Chemical profiling of M. oleifera …

Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies

MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …

Synthesis and biological evaluation of 1, 2, 3-triazole tethered thymol-1, 3, 4-oxadiazole derivatives as anticancer and antimicrobial agents

ASA Almalki, S Nazreen, AM Malebari, NM Ali… - Pharmaceuticals, 2021 - mdpi.com
A library of 1, 2, 3-triazole-incorporated thymol-1, 3, 4-oxadiazole derivatives (6–18)
hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8 …

Synthesis, antiproliferative, docking and DFT studies of benzimidazole derivatives as EGFR inhibitors

HA Alzahrani, MM Alam, AA Elhenawy… - Journal of Molecular …, 2022 - Elsevier
In the present work, new benzimidazole linked 1, 2, 3-triazole hybrids have been
synthesized and screened for antiproliferative and EGFR kinase inhibitory activities. The …

Design, synthesis and molecular docking studies of thymol based 1, 2, 3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast …

MM Alam, AM Malebari, N Syed, T Neamatallah… - Bioorganic & medicinal …, 2021 - Elsevier
Natural product produced by plants has been the backbone for numerous anticancer agents.
In the present work, natural bioactive thymol based 1, 2, 3-triazole hybrids have been …

Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs

A Olatunde, M Nigam, RK Singh, AS Panwar… - Cancer cell …, 2021 - Springer
Cancers are regarded as one of the main causes of death and result in high health burden
worldwide. The management of cancer include chemotherapy, surgery and radiotherapy …

An understanding of mechanism-based approaches for 1, 3, 4-oxadiazole scaffolds as cytotoxic agents and enzyme inhibitors

D Kumar, N Aggarwal, A Deep, H Kumar, H Chopra… - Pharmaceuticals, 2023 - mdpi.com
The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …

Synthesis, biological evaluation, and molecular docking of new benzimidazole-1, 2, 3-triazole hybrids as antibacterial and antitumor agents

S Ahmed Saleh Alzahrani, S Nazreen… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of benzimidazole-1, 2, 3-triazole hybrids have been successfully accomplished
by the Click chemistry of different aromatic azides and propargylated benzimidazole (4). The …