The location, physiology, pathology of hippocampus Melatonin MT2 receptor and MT2-selective modulators
Y Feng, X Jiang, W Liu, H Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …
Structural basis of the ligand binding and signaling mechanism of melatonin receptors
Q Wang, Q Lu, Q Guo, M Teng, Q Gong, X Li… - Nature …, 2022 - nature.com
Melatonin receptors (MT1 and MT2 in humans) are family AG protein–coupled receptors that
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …
Revealing Melatonin's Mysteries: Receptors, signaling pathways, and therapeutics applications
Melatonin (5-methoxy-acetyl tryptamine) is a sleep-inducing hormone, and the pineal gland
produces it in response to the circadian clock of darkness. In the body, MT1 and MT2 …
produces it in response to the circadian clock of darkness. In the body, MT1 and MT2 …
Synthesis, in silico, and biological evaluation of a borinic tryptophan-derivative that induces melatonin-like amelioration of cognitive deficit in male rat
M Barrón-González, MC Rosales-Hernández… - International Journal of …, 2022 - mdpi.com
Preclinical and clinical evidence supports melatonin and its analogues as potential
treatment for diseases involving cognitive deficit such as Alzheimer's disease. In this work …
treatment for diseases involving cognitive deficit such as Alzheimer's disease. In this work …
Cu-catalyzed oxidative denitrogenation of 3-aminoindazoles for the synthesis of isoquinolinones
Y Guo, PF Huang, BQ Xiong, JH Fan… - Organic & Biomolecular …, 2022 - pubs.rsc.org
A Cu-catalyzed oxidative dual arylation of active alkenes via the cleavage of two C–N bonds
of 3-aminoindazoles is presented for constructing isoquinolinones. Importantly, 3 …
of 3-aminoindazoles is presented for constructing isoquinolinones. Importantly, 3 …
One-Pot Synthesis of 3-(1, 2, 3, 4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1 (2H)-ones by DEAD-Promoted Oxidative Ugi–Wittig Reaction Starting from Phosphonium …
L Zhao, ML Yang, M Sun, MW Ding - Synlett, 2022 - thieme-connect.com
A new one-pot synthesis of 3-(1, 2, 3, 4-tetrahydroisoquinolin-1-yl)-isoquinolin-1 (2H)-ones
by DEAD-promoted oxidative Ugi–Wittig reaction was developed. The sequential reactions …
by DEAD-promoted oxidative Ugi–Wittig reaction was developed. The sequential reactions …
Mélatonine-Petit précis à l'usage des trop enthousiastes
JA Boutin - médecine/sciences, 2022 - medecinesciences.org
La mélatonine est une molécule naturelle dérivée du tryptophane. Son rôle est de servir de
relai entre la rythmicité jour/nuit et notre corps. Elle sert donc de marqueur circadien …
relai entre la rythmicité jour/nuit et notre corps. Elle sert donc de marqueur circadien …