Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Heterochiral β-peptide polymers combating multidrug-resistant cancers effectively without inducing drug resistance

N Shao, L Yuan, P Ma, M Zhou, X Xiao… - Journal of the …, 2022 - ACS Publications
Multidrug resistance to chemotherapeutic drugs is one of the major causes for the failure of
cancer treatment. Therefore, there is an urgent need to develop anticancer agents that can …

[HTML][HTML] Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

Z Lu, Y Wu, Z Cong, Y Qian, X Wu, N Shao, Z Qiao… - Bioactive materials, 2021 - Elsevier
It is an urgent need to tackle drug-resistance microbial infections that are associated with
implantable biomedical devices. Host defense peptide-mimicking polymers have been …

Low-dimensional nanomaterials for antibacterial applications

XL Hu, Y Shang, KC Yan, AC Sedgwick… - Journal of Materials …, 2021 - pubs.rsc.org
The excessive use of antibiotics has led to a rise in drug-resistant bacteria. These
“superbugs” are continuously emerging and becoming increasingly harder to treat. As a …

Design and Synthesis of 3-Hydroxy-pyridin-4(1H)-ones–Ciprofloxacin Conjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa

YY Wang, XY Zhang, XL Zhong, YJ Huang… - Journal of Medicinal …, 2023 - ACS Publications
Pseudomonas aeruginosa infections are often complicated by the fact that it can easily form
a biofilm that increases its resistance to antibiotics. Consequently, the development of novel …

Multifunctional antibiotic–host defense peptide conjugate kills bacteria, eradicates biofilms, and modulates the innate immune response

H Etayash, M Alford, N Akhoundsadegh… - Journal of Medicinal …, 2021 - ACS Publications
Effective anti-infective therapies are required to offset the rise in antibiotic resistance. A
novel vancomycin-innate defense regulator conjugate (V–IDR1018) was constructed with …

Low-molecular-weight polylysines with excellent antibacterial properties and low hemolysis

P Wan, Y Wang, W Guo, Z Song, S Zhang… - ACS Biomaterials …, 2022 - ACS Publications
The steady development of bacterial resistance has become a global public health issue,
and new antibacterial agents that are active against drug-resistant bacteria and less …

[HTML][HTML] Antimicrobial properties of spray-dried cellulose nanocrystals and metal oxide-based nanoparticles-in-microspheres

A Baldelli, H Etayash, H Oguzlu, R Mandal… - Chemical Engineering …, 2022 - Elsevier
Spray-dried nanoparticle-in-microsphere formulations, composed of aluminum oxide
nanoparticles (NPs), zinc oxide, zinc oxide NPs and cellulose nanocrystals (CNCs), with …

Amphiphilic nano-swords for direct penetration and eradication of pathogenic bacterial biofilms

C Zhou, Y Zhou, Y Zheng, Y Yu, K Yang… - … Applied Materials & …, 2023 - ACS Publications
Bacterial biofilms are major causes of persistent and recurrent infections and implant
failures. Biofilms are formable by most clinically important pathogens worldwide, such as …