Testosterone and cardiovascular disease

RA Kloner, C Carson, A Dobs, S Kopecky… - Journal of the American …, 2016 - jacc.org
Testosterone (T) is the principal male sex hormone. As men age, T levels typically fall.
Symptoms of low T include decreased libido, vasomotor instability, and decreased bone …

Neutrophils in post-myocardial infarction inflammation: damage vs. resolution?

SL Puhl, S Steffens - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Inflammation not only plays a crucial role in acute ischemic cardiac injury, but also
contributes to post-infarction repair and remodeling. Traditionally, neutrophils have been …

Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and …

C Perrino, P Ferdinandy, HE Bøtker… - Cardiovascular …, 2021 - academic.oup.com
Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and
morbidity in both men and women. Sex, however, affects several aspects of IHD, including …

Genetic, molecular, and cellular determinants of sex-specific cardiovascular traits

F Vaura, J Palmu, J Aittokallio, A Kauko… - Circulation …, 2022 - Am Heart Assoc
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic,
molecular, and cellular underpinnings of these differences are not well understood. A …

Sex differences in therapies against myocardial ischemia-reperfusion injury: from basic science to clinical perspectives

L Medzikovic, T Azem, W Sun, P Rejali, L Esdin… - Cells, 2023 - mdpi.com
Mortality from myocardial infarction (MI) has declined over recent decades, which could be
attributed in large part to improved treatment methods. Early reperfusion is the cornerstone …

Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress

PR do Val Lima, KS Ronconi, EA Morra… - Frontiers in …, 2023 - frontiersin.org
Introduction Clinical studies have shown that low levels of endogenous testosterone are
associated with cardiovascular diseases. Considering the intimate connection between …

Androgens and non-genomic vascular responses in hypertension

M Perusquía - Biochemical Pharmacology, 2022 - Elsevier
Arterial hypertension is a global public health concern. In the last few years, the interest in
androgen deficiency has been growing, and the association between androgens and high …

Synergistic effects of hormones on structural and functional maturation of cardiomyocytes and implications for heart regeneration

AM Galow, J Brenmoehl, A Hoeflich - Cellular and Molecular Life Sciences, 2023 - Springer
The limited endogenous regenerative capacity of the human heart renders cardiovascular
diseases a major health threat, thus motivating intense research on in vitro heart cell …

Circulating androgen concentrations and risk of incident heart failure in older men: the cardiovascular Health study

JN Njoroge, W Tressel, ML Biggs… - Journal of the …, 2022 - Am Heart Assoc
Background Circulating androgen concentrations in men decline with age and have been
linked to diabetes and atherosclerotic cardiovascular disease (ASCVD). A similar …

Testosterone, myocardial function, and mortality

VE Bianchi - Heart failure reviews, 2018 - Springer
The cardiovascular system is particularly sensitive to androgens, but some controversies
exist regarding the effect of testosterone on the heart. While among anabolic abusers, cases …