Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by
the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing …

Background Lung infections are among the most consequential manifestations of cystic
fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs …

Highly-effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator
therapy (HEMT) corrects the underlying molecular defect causing cystic fibrosis (CF) …

Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic
fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue …

Background Cystic fibrosis (CF), which is caused by mutations in the CF transmembrane
conductance regulator (CFTR), is characterised by chronic bacterial lung infection and …

Macrophage dysfunction has been well-described in Cystic Fibrosis (CF) and may contribute
to bacterial persistence in the lung. Whether CF macrophage dysfunction is related directly …

Triple combination therapy with the CFTR modulators elexacaftor (ELX), tezacaftor (TEZ)
and ivacaftor (IVA) has been qualified as a game changer in cystic fibrosis (CF). We provide …

Cystic fibrosis (CF), the most common genetically inherited disease in Caucasian
populations, is a multi-systemic life-threatening autosomal recessive disorder caused by …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel for
transport of chloride and bicarbonate anions. Functional roles of CFTR have been identified …

Abstract Background Elexacaftor/Tezacaftor/Ivacaftor (ETI) modulator therapy is often
associated with increased body mass index (BMI) in people with cystic fibrosis (CF). This is …