Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The mouse embryo has long been central to the study of mammalian development;
however, elucidating the cell behaviors governing gastrulation and the formation of tissues …

Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …

The germ cell lineage ensures reproduction and heredity. The mechanism for germ cell
specification in primates, including humans, has remained unknown. In primates, upon …

INTRODUCTION Only 2.4% of the 16.5-kb mitochondrial DNA (mtDNA) genome shows
homoplasmic variation at> 1% frequency in humans. Migration patterns have contributed to …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …

Each follicle represents the basic functional unit of the ovary. From its very initial stage of
development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte …