[HTML][HTML] Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

BJ Boyd, CAS Bergström, Z Vinarov, M Kuentz… - European Journal of …, 2019 - Elsevier
Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Continuous manufacturing–the Green Chemistry promise?

L Rogers, KF Jensen - Green chemistry, 2019 - pubs.rsc.org
Continuous manufacturing and Green Chemistry, are two promising approaches to
synthesis with underutilized potential that are gaining traction by the wider pharmaceutical …

Applications of artificial intelligence and machine learning algorithms to crystallization

C Xiouras, F Cameli, GL Quillo… - Chemical …, 2022 - ACS Publications
Artificial intelligence and specifically machine learning applications are nowadays used in a
variety of scientific applications and cutting-edge technologies, where they have a …

Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

A megatrend challenging analytical chemistry: biosensor and chemosensor concepts ready for the internet of things

M Mayer, AJ Baeumner - Chemical reviews, 2019 - ACS Publications
The Internet of Things (IoT) is a megatrend that cuts across all scientific and engineering
disciplines and establishes an integrating technical evolution to improve production …

Continuous crystallization processes in pharmaceutical manufacturing: A review

J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

[HTML][HTML] The future of pharmaceutical manufacturing sciences

J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

Bioprocessing in the digital age: the role of process models

H Narayanan, MF Luna, M von Stosch… - Biotechnology …, 2020 - Wiley Online Library
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling

F Destro, M Barolo - International journal of pharmaceutics, 2022 - Elsevier
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …