Digital design of the crystallization of an active pharmaceutical ingredient using a population balance model with a novel size dependent growth rate expression. From …
B Szilagyi, A Eren, JL Quon… - Crystal Growth & …, 2021 - ACS Publications
Prediction and control of the product properties in crystallization processes are practical
challenges in the pharmaceutical industry. Effective crystallization process design and …
challenges in the pharmaceutical industry. Effective crystallization process design and …
Engineering chemistry for the future of chemical synthesis
DE Fitzpatrick, SV Ley - Tetrahedron, 2018 - Elsevier
Synthesis is changing in response to our modern resource conscious world. The principles
of green chemistry are evolving as the interfaces and boundaries in science are less …
of green chemistry are evolving as the interfaces and boundaries in science are less …
Continuous crystallization and its potential use in drug substance Manufacture: A review
Interest in the continuous manufacturing in the pharmaceutical industry for the production of
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …
[HTML][HTML] Reactor design and selection for effective continuous manufacturing of pharmaceuticals
C Hu - Journal of Flow Chemistry, 2021 - Springer
Pharmaceutical production remains one of the last industries that predominantly uses batch
processes, which are inefficient and can cause drug shortages due to the long lead times or …
processes, which are inefficient and can cause drug shortages due to the long lead times or …
[HTML][HTML] Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning
Based on the concept of continuous manufacturing an end-to-end benchtop device was
developed unprecedented for the production of solid drug dosage forms by connecting flow …
developed unprecedented for the production of solid drug dosage forms by connecting flow …
Continuous Flow Chemistry with Solids: A Review
HLD Hayes, CJ Mallia - Organic Process Research & …, 2024 - ACS Publications
The effective handling of solids in a continuous flow process is one of the biggest perceived
challenges remaining for modern flow chemistry. This Review aims to consider some of the …
challenges remaining for modern flow chemistry. This Review aims to consider some of the …
Process intensification for pharmaceutical crystallization
J Wang, F Li, R Lakerveld - Chemical Engineering and Processing-Process …, 2018 - Elsevier
Process intensification (PI) provides great opportunities to drastically improve the
performance of chemical processes within many branches of chemical industry including the …
performance of chemical processes within many branches of chemical industry including the …
Protein nucleation and crystallization process with process analytical Technologies in a batch crystallizer
Protein crystallization has drawn great attention to replacing the traditional downstream
processing for protein-based pharmaceuticals due to its advantages in stability, storage, and …
processing for protein-based pharmaceuticals due to its advantages in stability, storage, and …
[HTML][HTML] Application of PAT-based feedback control approaches in pharmaceutical crystallization
Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …
[HTML][HTML] Flexible automation with compact NMR spectroscopy for continuous production of pharmaceuticals
S Kern, L Wander, K Meyer, S Guhl… - Analytical and …, 2019 - Springer
Modular plants using intensified continuous processes represent an appealing concept for
the production of pharmaceuticals. It can improve quality, safety, sustainability, and …
the production of pharmaceuticals. It can improve quality, safety, sustainability, and …