Digital design of the crystallization of an active pharmaceutical ingredient using a population balance model with a novel size dependent growth rate expression. From …

B Szilagyi, A Eren, JL Quon… - Crystal Growth & …, 2021 - ACS Publications
Prediction and control of the product properties in crystallization processes are practical
challenges in the pharmaceutical industry. Effective crystallization process design and …

Engineering chemistry for the future of chemical synthesis

DE Fitzpatrick, SV Ley - Tetrahedron, 2018 - Elsevier
Synthesis is changing in response to our modern resource conscious world. The principles
of green chemistry are evolving as the interfaces and boundaries in science are less …

Continuous crystallization and its potential use in drug substance Manufacture: A review

A Eren, F Civati, W Ma, JC Gamekkanda… - Journal of Crystal …, 2023 - Elsevier
Interest in the continuous manufacturing in the pharmaceutical industry for the production of
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …

[HTML][HTML] Reactor design and selection for effective continuous manufacturing of pharmaceuticals

C Hu - Journal of Flow Chemistry, 2021 - Springer
Pharmaceutical production remains one of the last industries that predominantly uses batch
processes, which are inefficient and can cause drug shortages due to the long lead times or …

[HTML][HTML] Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

A Balogh, A Domokos, B Farkas, A Farkas… - Chemical Engineering …, 2018 - Elsevier
Based on the concept of continuous manufacturing an end-to-end benchtop device was
developed unprecedented for the production of solid drug dosage forms by connecting flow …

Continuous Flow Chemistry with Solids: A Review

HLD Hayes, CJ Mallia - Organic Process Research & …, 2024 - ACS Publications
The effective handling of solids in a continuous flow process is one of the biggest perceived
challenges remaining for modern flow chemistry. This Review aims to consider some of the …

Process intensification for pharmaceutical crystallization

J Wang, F Li, R Lakerveld - Chemical Engineering and Processing-Process …, 2018 - Elsevier
Process intensification (PI) provides great opportunities to drastically improve the
performance of chemical processes within many branches of chemical industry including the …

Protein nucleation and crystallization process with process analytical Technologies in a batch crystallizer

W Tian, W Li, H Yang - Crystal Growth & Design, 2023 - ACS Publications
Protein crystallization has drawn great attention to replacing the traditional downstream
processing for protein-based pharmaceuticals due to its advantages in stability, storage, and …

[HTML][HTML] Application of PAT-based feedback control approaches in pharmaceutical crystallization

Y Gao, T Zhang, Y Ma, F Xue, Z Gao, B Hou, J Gong - Crystals, 2021 - mdpi.com
Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …

[HTML][HTML] Flexible automation with compact NMR spectroscopy for continuous production of pharmaceuticals

S Kern, L Wander, K Meyer, S Guhl… - Analytical and …, 2019 - Springer
Modular plants using intensified continuous processes represent an appealing concept for
the production of pharmaceuticals. It can improve quality, safety, sustainability, and …