The biopharmaceutical industry is still running in batch mode, mostly because it is highly
regulated. In the past, sensors were not readily available and in‐process control was mainly …

Drug substance purification by crystallization is a key interface in going from drug substance
synthesis to final formulation and can often be a bottleneck in process efficiency. There has …

Biotherapeutics, such as those derived from monoclonal antibodies (mAbs), are industrially
produced in controlled multiunit operation bioprocesses. Each unit operation contributes to …

As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a
growing need to effectively predict the product quality based on manufacturing or in-process …

This paper provides an overview of nonlinear state estimation techniques along with a
discussion on the challenges and opportunities for future work in the field. Emphasis is given …

Crystallization is one of the most important unit operations for production of active
pharmaceutical ingredients (API) in pharmaceutical industry. This work studied the impact of …

Purity is a critical quality attribute for both pharmaceutical and biopharmaceutical products.
The presence of impurities (solvents, salts, or byproducts of the synthetic path) in drugs can …

The conversion of [IrCl (COD)(IMes)](COD= cis, cis-1, 5-cyclooctadiene, IMes= 1, 3-bis (2, 4,
6-trimethyl-phenyl) imidazole-2-ylidene) in the presence of an excess of para-hydrogen (p …

Due to their size, conventional high performance liquid chromatographs (HPLCs) are difficult
to place close to a reaction vessel within a pharmaceutical manufacturing or development …

Using antisolvent crystallisation of salicylic acid as the model process, we report our
experimental investigation into the temporal and spatial steady states of solution …