Innate immunity is the first line of host defense against invading pathogens. The detection of
aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN …

The presence of cytosolic double-stranded DNA molecules can trigger multiple innate
immune signalling pathways which converge on the activation of an ER-resident innate …

Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and
are endogenously regulated by a low-level constitutive feedback loop. However, little is …

Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-
inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a …

The stimulator of interferon (IFN) genes (STING) pathway constitutes a highly important part
of immune responses against various cancers and infections. Consequently, administration …

Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …

Previous analyses of patients with SAVI revealed decreased CD4 1 T-cell populations and
normal CD14 1 monocyte levels within the population of PBMCs, 3 whereas our patient had …

To effectively defend against microbial pathogens, the host cells mount antiviral innate
immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes …

Regulation of IFN signaling is critical in host recognition and response to pathogens while its
dysregulation underlies the pathogenesis of several chronic diseases. STimulator of IFN …

Cyclic diadenylate monophosphate (c-di-AMP) is secreted by bacteria as a secondary
messenger. How immune cells detect c-di-AMP and initiate anti-bacterial immunity remains …