Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …

Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …

MicroRNAs (miRNAs) are found in nerve terminals, synaptic vesicles, and synaptosomes,
but it is unclear whether synaptic and cytosolic miRNA populations differ in Alzheimer's …

Abstract Background MicroRNA-455-3p is one of the highly conserved miRNAs involved in
multiple cellular functions in humans and we explored its relevance to learning and memory …

Cerebral hypometabolism of glucose, weight loss, and decreased food intake are
characteristic features of sporadic Alzheimer's disease (AD). A systematic study on the …

Deposition of extracellular plaques, primarily consisting of amyloid β peptide (Aβ), in the
brain is the confirmatory diagnostic of Alzheimer's disease (AD); however, the physiological …

Amyloid-β peptide (Aβ) plaque in the brain is the primary (post mortem) diagnostic criterion
of Alzheimer's disease (AD). The physiological role (s) of Aβ are poorly understood. We …

Over two decades have passed since the original discovery of amyloid precursor protein
(APP). While physiological function (s) of APP still remain a matter of debate, consensus …