Diabetic microvascular disease: an endocrine society scientific statement
EJ Barrett, Z Liu, M Khamaisi, GL King… - The Journal of …, 2017 - academic.oup.com
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Multi-target-directed ligands in Alzheimer's disease treatment
M Bajda, N Guzior, M Ignasik… - Current medicinal …, 2011 - ingentaconnect.com
Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
Alzheimer's disease due to loss of function: A new synthesis of the available data
KP Kepp - Progress in neurobiology, 2016 - Elsevier
Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …
cellular, and biochemical manifestations that are currently not understood in combination …
Synaptosome microRNAs regulate synapse functions in Alzheimer's disease
MicroRNAs (miRNAs) are found in nerve terminals, synaptic vesicles, and synaptosomes,
but it is unclear whether synaptic and cytosolic miRNA populations differ in Alzheimer's …
but it is unclear whether synaptic and cytosolic miRNA populations differ in Alzheimer's …
[HTML][HTML] MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease
Abstract Background MicroRNA-455-3p is one of the highly conserved miRNAs involved in
multiple cellular functions in humans and we explored its relevance to learning and memory …
multiple cellular functions in humans and we explored its relevance to learning and memory …
Altered serum levels of adipokines and insulin in probable Alzheimer's disease
VK Khemka, D Bagchi… - Journal of …, 2014 - content.iospress.com
Cerebral hypometabolism of glucose, weight loss, and decreased food intake are
characteristic features of sporadic Alzheimer's disease (AD). A systematic study on the …
characteristic features of sporadic Alzheimer's disease (AD). A systematic study on the …
The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner …
Deposition of extracellular plaques, primarily consisting of amyloid β peptide (Aβ), in the
brain is the confirmatory diagnostic of Alzheimer's disease (AD); however, the physiological …
brain is the confirmatory diagnostic of Alzheimer's disease (AD); however, the physiological …
Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating …
Amyloid-β peptide (Aβ) plaque in the brain is the primary (post mortem) diagnostic criterion
of Alzheimer's disease (AD). The physiological role (s) of Aβ are poorly understood. We …
of Alzheimer's disease (AD). The physiological role (s) of Aβ are poorly understood. We …
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells
S Brunholz, S Sisodia, A Lorenzo, C Deyts… - Experimental brain …, 2012 - Springer
Over two decades have passed since the original discovery of amyloid precursor protein
(APP). While physiological function (s) of APP still remain a matter of debate, consensus …
(APP). While physiological function (s) of APP still remain a matter of debate, consensus …