Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Dry eye can be caused by a variety of iatrogenic interventions. The increasing number of
patients looking for eye care or cosmetic procedures involving the eyes, together with a …

The tarsal glands of Meibom (glandulae tarsales) are large sebaceous glands located in the
eyelids and, unlike those of the skin, are unassociated with hairs. According to Duke-Elder …

The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …

Dry eye syndrome (DES) refers to a spectrum of ocular surface diseases with diverse and
frequently multiple aetiologies. The common feature of the various manifestations of DES is …

Oculomotor behavior and parameters are known to be affected by the allocation of attention
and could potentially be used to investigate attention disorders. We explored the oculomotor …

Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop
chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged …

INTRODUCTION: Safety pharmacology is integral to the non-clinical safety assessment of
new chemical entities prior to first administration to humans. The zebrafish is a well …

Over the past two decades considerable progress has been made in understanding the
ototoxic effects and mechanisms underlying loop diuretics. As typical representative of loop …

The in vitro and in vivo anti-mycobacterial activities of a number of phenothiazine
compounds are reviewed. These compounds, normally employed for the management of …