Sepsis exacerbates Alzheimer's disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden

VV Giridharan, CSG Catumbela, CHR Catalão… - Molecular …, 2023 - nature.com
While our understanding of the molecular biology of Alzheimer's disease (AD) has grown,
the etiology of the disease, especially the involvement of peripheral infection, remains a …

[HTML][HTML] Projecting prevalence of frailty and dementia and the economic cost of care in Japan from 2016 to 2043: a microsimulation modelling study

M Kasajima, K Eggleston, S Kusaka, H Matsui… - The Lancet Public …, 2022 - thelancet.com
Background Dementia and frailty often accompany one another in older age, requiring
complex care and resources. Available projections provide little information on their joint …

[HTML][HTML] Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented …

MA Maito, H Santamaría-García… - The Lancet Regional …, 2023 - thelancet.com
Background Global brain health initiatives call for improving methods for the diagnosis of
Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented …

Sensitive dual-mode sensing platform for Amyloid β detection: Combining dual Z-scheme heterojunction enhanced photoelectrochemistry analysis and dual …

Y Bu, K Wang, X Yang, G Nie - Biosensors and Bioelectronics, 2023 - Elsevier
As a tumor biomarker, the accumulation of amyloid β oligomers (Aβo) in the brain has been
suggested as a key feature in the pathogenesis and progression of Alzheimer's disease …

[HTML][HTML] Gut microbiota composition in patients with neurodegenerative disorders (Parkinson's and Alzheimer's) and healthy controls: a systematic review

FS Heravi, K Naseri, H Hu - Nutrients, 2023 - mdpi.com
This systematic review aims to provide a comprehensive understanding of the current
literature regarding gut microbiota composition in patients with Parkinson's disease (PD) …

[HTML][HTML] The relationship of omega-3 fatty acids with dementia and cognitive decline: evidence from prospective cohort studies of supplementation, dietary intake, and …

BZ Wei, L Li, CW Dong, CC Tan, W Xu… - The American journal of …, 2023 - Elsevier
Previous data have linked omega-3 fatty acids with risk of dementia. We aimed to assess the
longitudinal relationships of omega-3 polyunsaturated fatty acid intake as well as blood …

[HTML][HTML] Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease

D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

[HTML][HTML] Treatment of Alzheimer's disease: beyond symptomatic therapies

FR Buccellato, M D'Anca, GM Tartaglia… - International Journal of …, 2023 - mdpi.com
In an ever-increasing aged world, Alzheimer's disease (AD) represents the first cause of
dementia and one of the first chronic diseases in elderly people. With 55 million people …

[HTML][HTML] An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease

Y Ratan, A Rajput, S Maleysm, A Pareek, V Jain… - Biomedicines, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis

K Li, A Li, Y Mei, J Zhao, Q Zhou, Y Li, M Yang… - Environmental Pollution, 2023 - Elsevier
Alterations in the concentrations of trace elements may play a vital role in Alzheimer
dementia progression. However, previous research results are inconsistent, and there is still …