Deciphering the cell-state transitions underlying immune adaptation across time is
fundamental for advancing biology. Empirical in vivo genomic technologies that capture …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

Much progress has been made recently in single-cell chromosome conformation capture
technologies. However, a method that allows simultaneous profiling of chromatin …

Clinically relevant immunological biomarkers that discriminate between diverse
hypofunctional states of tumor-associated CD8+ T cells remain disputed. Using multiomics …

The recent breakthrough of single-cell RNA velocity methods brings attractive promises to
reveal directed trajectory on cell differentiation, states transition and response to …

Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …

Lymphocytes are key for immune surveillance of tumors, but our understanding of the spatial
organization and physical interactions that facilitate lymphocyte anti-cancer functions is …

Schwann cell precursors (SCPs) are nerve‐associated progenitors that can generate
myelinating and non‐myelinating Schwann cells but also are multipotent like the neural …

RNA velocity has been rapidly adopted to guide interpretation of transcriptional dynamics in
snapshot single-cell data; however, current approaches for estimating RNA velocity lack …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …