Alzheimer's disease and its treatment by different approaches: A review
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …
development and interrupts neurocognitive function. This neuropathological condition is …
[HTML][HTML] Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases
P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …
antioxidant systems leads to a condition known as oxidative stress. The main source of free …
[HTML][HTML] Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
[HTML][HTML] Gut microbiota and dysbiosis in Alzheimer's disease: implications for pathogenesis and treatment
S Liu, J Gao, M Zhu, K Liu, HL Zhang - Molecular neurobiology, 2020 - Springer
Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …
significant research over the past decade. The broadening of the term “microbiota-gut-brain …
The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis
T Ashleigh, RH Swerdlow, MF Beal - Alzheimer's & Dementia, 2023 - Wiley Online Library
To promote new thinking of the pathogenesis of Alzheimer's disease (AD), we examine the
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …
Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
[HTML][HTML] Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …
[HTML][HTML] Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …