Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

The amyloid-β peptide (Aβ) is widely considered to be the major toxic agent in the
pathogenesis of Alzheimer's disease, a condition which afflicts approximately 36 million …

High density lipoproteins (HDL) are susceptible to structural modifications mediated by
various mechanisms including oxidation, glycation, homocysteinylation or enzymatic …

Objective: Several lines of evidence indicate that a decrease in the CSF concentration of
amyloid β42 (Aβ42) is a potential biomarker for incident Alzheimer disease. In contrast …

Oxidative stress is important in the pathogenesis of Alzheimer's disease (AD). The brain
contains high levels of oxidizable lipids that must be protected by antioxidants. Low …

The brains of individuals diagnosed with Alzheimer's disease (AD) are characterized by
amyloid plaques, of which the major component is Aβ peptide. Excessive Cu and Fe ions …

Oxidative stress plays a key role in Alzheimer's disease (AD). In addition, the abnormally
high Cu2+ ion concentrations present in senile plaques has provoked a substantial interest …

Human amylin-derived oligomers and aggregates are believed to play an important role in
the pathogenesis of type II diabetes mellitus (T2DM). In addition to amylin-evoked cell …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
dys-homeostasis of biometal metabolism, the extracellular accumulation of neurotoxic …

Background: Sporadic Alzheimer's disease (sAD) lacks a unifying hypothesis that can
account for the lipid peroxidation observed early in the disease, enrichment of ApoE in the …