Flavivirus replication in host cells requires the formation of replication and assembly
complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These …

Flaviviruses are globally distributed pathogens causing millions of human infections every
year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or …

Positive-stranded RNA viruses, such as hepatitis C virus (HCV), assemble their viral
replication complexes by remodeling host intracellular membranes to a membranous web …

Efficient antiviral immunity requires interference with virus replication at multiple layers
targeting diverse steps in the viral life cycle. We describe here a novel flavivirus inhibition …

How can anterograde membrane trafficking be modulated by physiological cues? A screen
of Golgi-associated proteins revealed that the ARF-GEF GBF1 can selectively modulate the …

Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the
world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped …

Viral RNAs contain the information needed to synthesize their own proteins, to replicate, and
to spread to susceptible cells. However, due to their reduced coding capacity RNA viruses …

GBF1 has emerged as a host factor required for the replication of positive-sense single-
stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 …

The hepatitis E virus (HEV) genome is a single‐stranded, positive‐sense RNA that encodes
three proteins including the ORF1 replicase. Mechanisms of HEV replication in host cells are …

Viperin is an interferon (IFN)-stimulated gene product, which is part of the first line of the
intracellular response against viral infection. It is a potent antiviral protein, strongly …