Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease

P Tan, L Jin, X Qin, B He - Frontiers in Pharmacology, 2022 - frontiersin.org
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide;
however, there are currently limited treatments for NAFLD. The disease spectrum includes …

Preventive and therapeutic effects of natural products and herbal extracts on nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Y Cao, X Fang, M Sun, Y Zhang, M Shan… - Phytotherapy …, 2023 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common condition that is prevalent in patients
who consume little or no alcohol, and is characterized by excessive fat accumulation in the …

[HTML][HTML] Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis

K Yin, D Wang, Y Zhang, H Lu, Y Wang… - Journal of Advanced …, 2023 - Elsevier
Introduction Microplastic pollution seriously threatens the health and safety of humans and
wildlife. Avian is one of the main species endangered by microplastics. However, the …

Polysaccharides from Enteromorpha prolifera alleviate hypercholesterolemia via modulating the gut microbiota and bile acid metabolism

C Yang, S Huang, Z Lin, H Chen, C Xu, Y Lin, H Sun… - Food & Function, 2022 - pubs.rsc.org
Polysaccharides from Enteromorpha prolifera (EP) possess multiple biological activities,
while the role of EP in hypercholesterolemia and its relationship with the gut microbiota have …

Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and …

MQ Wang, KH Zhang, FL Liu, R Zhou, Y Zeng, AL Chen… - Phytomedicine, 2024 - Elsevier
Background Cholestatic liver diseases (CLD) comprise a variety of disorders of bile
formation, which causes chronic exposure to bile acid (BA) in the liver generally and results …

[HTML][HTML] Alternative pathway of bile acid biosynthesis contributes to ameliorate NASH after induction of NAMPT/NAD+/SIRT1 axis

N Yang, R Sun, X Zhang, J Wang, L Wang… - Biomedicine & …, 2023 - Elsevier
Non-alcoholic steatohepatitis (NASH) is emerging as a serious liver disorder characterized
by hepatic steatosis and liver inflammation. Nicotinamide adenine dinucleotide (NAD+) and …

Hyperoside prevents high-fat diet-induced obesity by increasing white fat browning and lipophagy via CDK6-TFEB pathway

S Cheng, X Ni, Y Yao, Y Sun, X Yu, D Xia… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Hypericum perforatum L.(genus Hypericum, family
Hypericaceae) is a flowering plant native to Europe, North Africa and Asia, which can be …

Hyperoside as a potential natural product targeting oxidative stress in liver diseases

E Jang - Antioxidants, 2022 - mdpi.com
Hyperoside (Hyp), also known as quercetin-3-O-galactoside or 3-O-β-D-galactopyranosyl, is
a well-known flavonol glycoside that is abundant in various fruits, vegetables, and medicinal …

Combined exposure to PM2. 5 and high-fat diet facilitates the hepatic lipid metabolism disorders via ROS/miR-155/PPARγ pathway

Z Du, L Lin, Y Li, M Sun, Q Liang, Z Sun… - Free Radical Biology and …, 2022 - Elsevier
Environmental fine particulate matter (PM 2.5), which has attracted worldwide attention, is
associated with the progression of metabolic-associated fatty liver disease (MAFLD) …

Protective effect and mechanism of lactoferrin combined with hypoxia against high-fat diet induced obesity and non-alcoholic fatty liver disease in mice

JX Wu, Q He, Y Zhou, JY Xu, Z Zhang, CL Chen… - International Journal of …, 2023 - Elsevier
Obesity is a global epidemic, it can induce glucose and lipid metabolism disorder and non-
alcoholic fatty liver disease (NAFLD). This study explored a new way to control weight and …