BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …

Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure> 90% of
girls and young women affected by disorders requiring such treatment. However, the ovaries …

In women,∼ 10% of cancers occur in those< 45 years old. Chemotherapy, radiotherapy and
bone marrow transplantation can cure> 90% of girls and young women with diseases that …

The classical view of ovarian follicle development is that it is regulated by the hypothalamic-
pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the …

Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …

Ovarian tissue cryopreservation is currently proposed to young cancer patients to preserve
their fertility before radiochemotherapy. The potential risk is that the tissue might harbor …

Introduction. Premature ovarian failure (POF) can occur naturally at an early age or be due
to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to …

The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility
preservation option for young women. The only available option to restore fertility using this …

STUDY QUESTION Can a reconstructed ovary using decellularized human ovarian tissue
(DCT) support survival of pre-antral stage follicles? SUMMARY ANSWER We have …

BACKGROUND Female cancer patients are offered 'banking'of gametes before starting
fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between …