The expanding role of predictive toxicology: an update on the (Q) SAR models for mutagens and carcinogens
R Benigni, TI Netzeva, E Benfenati… - … Science and Health …, 2007 - Taylor & Francis
Different regulatory schemes worldwide, and in particular, the preparation for the new
REACH (Registration, Evaluation and Authorization of CHemicals) legislation in Europe …
REACH (Registration, Evaluation and Authorization of CHemicals) legislation in Europe …
Distributed structure-searchable toxicity (DSSTox) public database network: a proposal
AM Richard, CLR Williams - Mutation Research/Fundamental and …, 2002 - Elsevier
The ability to assess the potential genotoxicity, carcinogenicity, or other toxicity of
pharmaceutical or industrial chemicals based on chemical structure information is a highly …
pharmaceutical or industrial chemicals based on chemical structure information is a highly …
Predictivity and reliability of QSAR models: The case of mutagens and carcinogens
R Benigni, C Bossa - Toxicology mechanisms and methods, 2008 - Taylor & Francis
This paper presents the results from an evaluation of the noncommercial,(quantitative)
structure-activity relationship ([Q] SAR) models for the prediction of mutagenicity and …
structure-activity relationship ([Q] SAR) models for the prediction of mutagenicity and …
Structural analysis and predictive value of the rodent in vivo micronucleus assay results
R Benigni, C Bossa, A Worth - Mutagenesis, 2010 - academic.oup.com
In vivo genotoxicity studies—shortly followed by carcinogenicity—are posing high demand
for test-related recourses in terms of animal lives and resources. Among those, the …
for test-related recourses in terms of animal lives and resources. Among those, the …
Evaluation of 10 aliphatic halogenated hydrocarbons in the mouse bone marrow micronucleus test
R Crebelli, A Carere, P Leopardi, L Conti, F Fassio… - …, 1999 - academic.oup.com
Ten halogenated aliphatic hydrocarbons (carbon tetrachloride, 1-chlorohexane, 2, 3-
dichlorobutane, 1, 2-dichloroethane, 1, 2-dichloroethylene, 1, 3-dichloropropane …
dichlorobutane, 1, 2-dichloroethane, 1, 2-dichloroethylene, 1, 3-dichloropropane …
An evaluation of the carcinogenic hazard of 1, 4-dichlorobenzene based on internationally recognized criteria
JA Barter, JH Sherman - Regulatory Toxicology and Pharmacology, 1999 - Elsevier
1, 4-Dichlorobenzene (1, 4-DCB) was shown to induce the formation of male rat renal tubule
tumors and male and female mouse liver tumors when administered in a chronic bioassay …
tumors and male and female mouse liver tumors when administered in a chronic bioassay …
The rodent bone marrow micronucleus assay: contrast between its sensitivity to human carcinogens and its insensitivity to NTP rodent carcinogens
J Ashby, H Tinwell - … Research/Fundamental and Molecular Mechanisms of …, 1996 - Elsevier
The rodent bone marrow micronucleus (MN) assay occupies a critical position in the
accompanying schemes to detect potential human carcinogens and germ cell mutagens …
accompanying schemes to detect potential human carcinogens and germ cell mutagens …
[PDF][PDF] Biological evaluation of medical devices. Part 3: Tests for genotoxicity, carcinogenicity and reproductive toxicity
ICSICS ICS - 2015 - standard.md
Standarde moldovene adoptate Page 1 Standarde moldovene adoptate Anexa nr. 1 la Hotărîrea
nr. 17 din 12.02.2015 # Indicativul standardului moldovean Titlul standardului în limba română …
nr. 17 din 12.02.2015 # Indicativul standardului moldovean Titlul standardului în limba română …
Alkylpyridines and Miscellaneous Organic Nitrogen Compounds
MK Peterson - Patty's Toxicology, 2001 - Wiley Online Library
This chapter provides a broad overview of topics related to the occupational use and
exposure to a variety of miscellaneous nitrogen‐containing compounds. Topics addressed …
exposure to a variety of miscellaneous nitrogen‐containing compounds. Topics addressed …
[引用][C] Alkylpyridines and miscellaneous organic nitrogen compounds
GL Kennedy Jr - Patty's Toxicology, 2001 - Wiley Online Library
This chapter covers additional aliphatic and aromatic compounds that contain one or more
nitrogen atoms in their structures and follows those discussed in Chapter 59. Pyridine and its …
nitrogen atoms in their structures and follows those discussed in Chapter 59. Pyridine and its …