It is now generally accepted that aging and eventual death of multicellular organisms is to a
large extent related to macromolecular damage by mitochondrially produced reactive …

In a literature survey, Chernoff et al.(2017) dismissed the hypothesis that chronic exposure
to β-N-methylamino-L-alanine (BMAA) may be a risk factor for progressive …

Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …

Though a multi-facetted disorder, Parkinson's disease is prototypically characterized by
neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars …

Elevated levels of oxidized proteins are reported in diseased tissue from age‐related
pathologies such as atherosclerosis, neurodegenerative disorders, and cataract. Unlike the …

The lysosome is a redox-active compartment containing low-mass iron and copper liberated
by autophagic degradation of metalloproteins. The acidic milieu and high concentration of …

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by a preferential
degeneration of dopaminergic neurons in the substantia nigra pars compacta. This results in …

In the late 1990s ethnobotanist Paul Alan Cox visited the in-digenous Chamorro people of
Guam, sleuthing for cancer cures in the lush rainforest. He soon stumbled upon troubling …

Despite astounding diversity in their structure and function, proteins are constructed from 22
protein or 'canonical'amino acids. Hundreds of amino acid analogues exist; many occur …

A major trend in recent Parkinson's disease (PD) research is the investigation of biological
markers that could help in identifying at-risk individuals or to track disease progression and …