Antiviral drug resistance of human cytomegalovirus

NS Lurain, S Chou - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

[HTML][HTML] CMV: prevention, diagnosis and therapy

CN Kotton - American Journal of Transplantation, 2013 - Elsevier
Cytomegalovirus (CMV) is the most common infection after organ transplantation and has a
major impact on morbidity, mortality and graft survival. Optimal prevention, diagnosis and …

International consensus guidelines on the management of cytomegalovirus in solid organ transplantation

CN Kotton, D Kumar, AM Caliendo, A Åsberg… - …, 2010 - journals.lww.com
Cytomegalovirus (CMV) remains one of the most common infections after solid organ
transplantation, resulting in significant morbidity, graft loss, and occasional mortality …

Antiviral drug resistance: mechanisms and clinical implications

L Strasfeld, S Chou - Infectious Disease Clinics, 2010 - id.theclinics.com
In the setting of intensive immunosuppression for the management of rejection in solid organ
transplant (SOT) recipients, or graft-versus-host disease (GVHD) in hematopoietic stem cell …

[HTML][HTML] Human cytomegalovirus latency and reactivation in allogeneic hematopoietic stem cell transplant recipients

L Stern, B Withers, S Avdic, D Gottlieb… - Frontiers in …, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) reactivation is a major infectious cause of morbidity and
mortality after allogeneic hematopoietic stem cell transplantation (HSCT). HCMV is a …

How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients

F El Chaer, DP Shah… - Blood, The Journal of the …, 2016 - ashpublications.org
Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell
transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating …

Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance

J Piret, G Boivin - Antiviral research, 2019 - Elsevier
The prevention and treatment of human cytomegalovirus (HCMV) infections is based on the
use of antiviral agents that currently target the viral DNA polymerase and that may cause …

Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir

S Chou - Reviews in medical virology, 2008 - Wiley Online Library
Mutations in the human CMV UL97 kinase gene are a major mechanism of viral resistance
to two anti‐CMV drugs, ganciclovir (GCV) and maribavir (MBV). GCV, the most widely used …

Herpesvirus DNA polymerases: Structures, functions and inhibitors

K Zarrouk, J Piret, G Boivin - Virus research, 2017 - Elsevier
Human herpesviruses are large double-stranded DNA viruses belonging to the
Herpesviridae family. These viruses have the ability to establish lifelong latency into the host …

Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation

MY Shapira, IB Resnick, S Chou… - Clinical Infectious …, 2008 - academic.oup.com
This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell
transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA …