The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

Pancreatic cancer tends to be highly resistant to current therapy and remains one of the
great challenges in biomedicine with very low 5-year survival rates. Here, we report that …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …

The activation of STING in cancer cells is conducive to inducing apoptosis of cancer cells
and activating immune responses for immunotherapy by improving antigen presentation …

Abstract cGAS is a sensor of cytosolic DNA and responds equally to exogenous and
endogenous DNA. After recognition of cytosolic dsDNA or ssDNA, cGAS synthesizes the …

Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP
(cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune …

Cervical cancer is the most common gynecologic cancer, etiologically related to persistent
infection of human papillomavirus (HPV). Both the host innate immunity system and the …

Stimulator of interferon genes (STING) plays a crucial role in human innate immune system,
which is gradually concerned following the emerging immunotherapy. Activated STING …

While the function of cGAS/STING signalling axis in the innate immune response to DNA
viruses is well deciphered, increasing evidence demonstrates its significant contribution in …