Articular cartilage damage and chondrocyte apoptosis are among the distinguishing
features of osteoarthritis.(R)-N-(benzimidazol-2-yl)-1, 2, 3, 4-tetrahydro-1-naphtylamine …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows
unparalleled therapeutic resistance. Oncolytic viruses have emerged as a new treatment …

Background As an essential regulator of type I interferon (IFN) response, TMEM173
participates in immune regulation and cell death induction. In recent studies, activation of …

Background and methods: Host genomic alterations are closely related to dysfunction of
CD4+ T lymphocytes in the HIV–host interplay. However, the roles of aberrant DNA …

Skin, the largest organ in the body, provides a passive physical barrier against infection and
contains elements of the innate and adaptive immune systems. Skin consists of various …

固有免疫系统通过模式识别受体识别病原微生物表面的病原相关分子模式启动固有免疫反应,
经级联信号转导, 激活下游转录因子NF-κB 和干扰素调节因子IRFs, 进而产生炎性细胞因子以及 …

Cytosolic DNAs promote inflammatory responses upon detection by the cyclic GMP-AMP
(cGAMP) synthase (cGAS). It has been thus suggested that cGAS downregulation is an …

The simultaneous abuse of alcohol-cocaine is known to cause stronger and more
unpredictable cellular damage in the liver, heart, and brain. However, the crosstalk between …

Undifferentiated pleomorphic sarcoma (UPS) is one of the most common, aggressive, and
metastatic soft tissue sarcomas in adults. Generally, UPS are unresponsive to conventional …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease and a common
complication of SLE is lupus nephritis (LN) during which lupus autoantibodies and …