Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

T Ni, Q Jiang, PC Ng, J Shen, H Dou, Y Zhu… - Nature …, 2023 - nature.com
Carboxysomes are a paradigm of self-assembling proteinaceous organelles found in nature,
offering compartmentalisation of enzymes and pathways to enhance carbon fixation. In α …

Reconstituting the complete biosynthesis of D-lysergic acid in yeast

G Wong, LR Lim, YQ Tan, MK Go, DJ Bell… - Nature …, 2022 - nature.com
The ergot alkaloids are a class of natural products known for their pharmacologically
privileged molecular structure that are used in the treatment of neurological ailments, such …

Modeling bacterial microcompartment architectures for enhanced cyanobacterial carbon fixation

DS Trettel, SL Pacheco, AK Laskie… - Frontiers in Plant …, 2024 - frontiersin.org
The carboxysome is a bacterial microcompartment (BMC) which plays a central role in the
cyanobacterial CO 2-concentrating mechanism. These proteinaceous structures consist of …

Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus

RQ Zhou, YL Jiang, H Li, P Hou, WW Kong, JX Deng… - Nature Plants, 2024 - nature.com
Carboxysomes are bacterial microcompartments that encapsulate the enzymes RuBisCO
and carbonic anhydrase in a proteinaceous shell to enhance the efficiency of photosynthetic …

Probing the internal pH and permeability of a carboxysome shell

J Huang, Q Jiang, M Yang, GF Dykes… - …, 2022 - ACS Publications
The carboxysome is a protein-based nanoscale organelle in cyanobacteria and many
proteobacteria, which encapsulates the key CO2-fixing enzymes ribulose-1, 5-bisphosphate …

α-carboxysome size is controlled by the disordered scaffold protein CsoS2

LM Oltrogge, AW Chen, T Chaijarasphong… - Biochemistry, 2023 - ACS Publications
Carboxysomes are protein microcompartments that function in the bacterial CO2
concentrating mechanism (CCM) to facilitate CO2 assimilation. To do so, carboxysomes …

Bacterial microcompartments as a next-generation metabolic engineering tool: utilizing nature's solution for confining challenging catabolic pathways

L Doron, CA Kerfeld - Biochemical Society Transactions, 2024 - portlandpress.com
Advancements in synthetic biology have facilitated the incorporation of heterologous
metabolic pathways into various bacterial chassis, leading to the synthesis of targeted …

[PDF][PDF] Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome

SL Evans, MMJ Al-Hazeem, D Mann, N Smetacek… - Structure, 2023 - cell.com
Carboxysomes are proteinaceous bacterial microcompartments that sequester the key
enzymes for carbon fixation in cyanobacteria and some proteobacteria. They consist of a …

Interfacial Assembly of Bacterial Microcompartment Shell Proteins in Aqueous Multiphase Systems

AADT Abeysinghe, EJ Young, AT Rowland… - Small, 2024 - Wiley Online Library
Compartments are a fundamental feature of life, based variously on lipid membranes,
protein shells, or biopolymer phase separation. Here, this combines self‐assembling …

Inferring assembly-curving trends of bacterial micro-compartment shell hexamers from crystal structure arrangements

LF Garcia-Alles, M Fuentes-Cabrera… - PLOS Computational …, 2023 - journals.plos.org
Bacterial microcompartments (BMC) are complex macromolecular assemblies that
participate in varied chemical processes in about one fourth of bacterial species. BMC …