The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer
B Zhang, Q Wu, B Li, D Wang, L Wang, YL Zhou - Molecular cancer, 2020 - Springer
Background The epigenetic regulation of immune response has been demonstrated in
recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) …
recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) …
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N 6 …
sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N 6 …
m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to …
D Jin, J Guo, Y Wu, J Du, L Yang, X Wang, W Di… - Journal of hematology & …, 2019 - Springer
Background METTL3 is an RNA methyltransferase that mediates m 6 A modification and is
implicated in mRNA biogenesis, decay, and translation. However, the biomechanism …
implicated in mRNA biogenesis, decay, and translation. However, the biomechanism …
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Q Lan, PY Liu, JL Bell, JY Wang, S Hüttelmaier… - Cancer research, 2021 - AACR
Abstract RNA N6-methyladenosine (m6A) modification occurs in approximately 25% of
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
Gene2vec: gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA
N 6-Methyladenosine (m6A) refers to methylation modification of the adenosine nucleotide
acid at the nitrogen-6 position. Many conventional computational methods for identifying N 6 …
acid at the nitrogen-6 position. Many conventional computational methods for identifying N 6 …
The m6A epitranscriptome: transcriptome plasticity in brain development and function
I Livneh, S Moshitch-Moshkovitz, N Amariglio… - Nature Reviews …, 2020 - nature.com
The field of epitranscriptomics examines the recently deciphered form of gene expression
regulation that is mediated by type-and site-specific RNA modifications. Similarly to the role …
regulation that is mediated by type-and site-specific RNA modifications. Similarly to the role …
The role of m6A modification in physiology and disease
C Yang, Y Hu, B Zhou, Y Bao, Z Li, C Gong… - Cell death & …, 2020 - nature.com
Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …
m6A modification in RNA: biogenesis, functions and roles in gliomas
Y Zhang, X Geng, Q Li, J Xu, Y Tan, M Xiao… - Journal of Experimental …, 2020 - Springer
The chemical modification of RNA is a newly discovered epigenetic regulation mechanism
in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) …
in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) …