Advances in targeted therapy for esophageal cancer

YM Yang, P Hong, WW Xu, QY He, B Li - Signal transduction and …, 2020 - nature.com
Esophageal cancer (EC) is one of the most lethal cancers in the world, and its morbidity and
mortality rates rank among the top ten in China. Currently, surgical resection, radiotherapy …

Cholangiocarcinoma: Epidemiology and risk factors

SA Khan, S Tavolari, G Brandi - Liver International, 2019 - Wiley Online Library
Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction
between host‐specific genetic background and multiple risk factors. Globally, CCA …

Inflammation: gearing the journey to cancer

JK Kundu, YJ Surh - Mutation Research/Reviews in Mutation Research, 2008 - Elsevier
Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer

LR Howe, K Subbaramaiah, CA Hudis… - Clinical cancer …, 2013 - AACR
The increasing rate of obesity worldwide is predicted to be associated with a surge in
diseases. Notably, obesity has been linked to approximately 20% of cancer cases in the …

Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer

PG Morris, CA Hudis, D Giri, M Morrow… - Cancer prevention …, 2011 - AACR
Obesity is a risk factor for the development of hormone receptor–positive breast cancer in
postmenopausal women and has been associated with an increased risk of recurrence and …

The role of inflammation in lung cancer

M Gomes, AL Teixeira, A Coelho, A Araujo… - Inflammation and …, 2014 - Springer
Lung cancer remains a serious public health problem and is the first cause of cancer death
worldwide, and the overall 5-year survival rate for all stages is 14–17% for Non-small-cell …

The role of herbs and spices in cancer prevention

CM Kaefer, JA Milner - The Journal of nutritional biochemistry, 2008 - Elsevier
Historically, herbs and spices have enjoyed a rich tradition of use for their flavor
enhancement characteristics and for their medicinal properties. The rising prevalence of …

NF-κB signaling pathway, inflammation and colorectal cancer

S Wang, Z Liu, L Wang, X Zhang - Cellular & molecular immunology, 2009 - nature.com
There is growing evidence for a connection between inflammation and tumor development,
and the nuclear factor kappa B (NF-κB), a proinflammatory transcription factor, is …

Fold change of nuclear NF-κB determines TNF-induced transcription in single cells

REC Lee, SR Walker, K Savery, DA Frank, S Gaudet - Molecular cell, 2014 - cell.com
In response to tumor necrosis factor (TNF), NF-κB enters the nucleus and promotes
inflammatory and stress-responsive gene transcription. Because NF-κB deregulation is …

The epidemiology and pathogenesis of neoplasia in the small intestine

D Schottenfeld, JL Beebe-Dimmer, FD Vigneau - Annals of epidemiology, 2009 - Elsevier
PURPOSE: The mucosa of the small intestine encompasses about 90% of the luminal
surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer …