[HTML][HTML] Myocardial ischemia/reperfusion: translational pathophysiology of ischemic heart disease

G Heusch - Med, 2024 - cell.com
Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

Colchicine's Role in Cardiovascular Disease Management

LF Buckley, P Libby - Arteriosclerosis, Thrombosis, and Vascular …, 2024 - Am Heart Assoc
Colchicine—an anti-inflammatory alkaloid—has assumed an important role in the
management of cardiovascular inflammation≈ 3500 years after its first medicinal use in …

[HTML][HTML] Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function

X Jiang, X Ding, J Wei, X Lv, Y Zhang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Gingival inflammation and alveolar bone loss are characteristic manifestations of
periodontitis. Interleukin (IL)-1β, the maturation of which is mainly regulated by NOD-like …

Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches

A Vulpetti, JM Rondeau, MH Bellance… - Journal of Medicinal …, 2024 - ACS Publications
Human interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a critical role in the
regulation of the immune response and the development of various inflammatory diseases …

Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway

Z Xu, Z Ma, X Zhao, B Zhang - Molecular and Cellular Biochemistry, 2024 - Springer
Obesity has been identified as an independent risk factor for cardiovascular disease. Recent
reports have highlighted the significance of stimulator of interferon genes (STING)-NOD-like …

Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation

A Niskala, J Heijman, D Dobrev… - British Journal of …, 2024 - Wiley Online Library
Inflammatory signalling via the nod‐like receptor (NLR) family pyrin domain‐containing
protein‐3 (NLRP3) inflammasome has recently been implicated in the pathophysiology of …

Role of Colchicine in Cardiovascular Disease Management

LF Buckley, P Libby - Arteriosclerosis, Thrombosis, and Vascular …, 2024 - Am Heart Assoc
Colchicine—an anti-inflammatory alkaloid—has assumed an important role in the
management of cardiovascular inflammation≈ 3500 years after its first medicinal use in …

[HTML][HTML] The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment

L Ramos-Regalado, S Alcover, L Badimon, G Vilahur - Cells, 2024 - mdpi.com
Myocardial infarction (MI) sets off a complex inflammatory cascade that is crucial for effective
cardiac healing and scar formation. Yet, if this response becomes excessive or uncontrolled …

Therapeutic potential of cannabidiol (CBD) in the treatment of cardiovascular diseases

NM Naya, J Kelly, A Hogwood, A Abbate… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Cannabidiol (CBD) is the primary non-psychoactive chemical derived from
Cannabis Sativa, and its growing popularity is due to its potential therapeutic properties …

[HTML][HTML] Targeting Epigenetic and Post-translational Modifications Regulating Pyroptosis for the Treatment of Inflammatory Diseases

YH Yang, TN Zhang, CF Liu, N Yang - Pharmacological Research, 2024 - Elsevier
Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-
related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten …