Hormesis determines lifespan
EJ Calabrese, M Nascarella, P Pressman… - Ageing Research …, 2024 - Elsevier
This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …
Insulin and aging–a disappointing relationship
H Kolb, K Kempf, S Martin - Frontiers in Endocrinology, 2023 - frontiersin.org
Experimental studies in animal models of aging such as nematodes, fruit flies or mice have
observed that decreased levels of insulin or insulin signaling promotes longevity. In humans …
observed that decreased levels of insulin or insulin signaling promotes longevity. In humans …
Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans
I Mora, A Pérez-Santamaria, J Tortajada-Pérez… - Cells, 2023 - mdpi.com
The human lifespan has increased over the past century; however, healthspans have not
kept up with this trend, especially cognitive health. Among nutrients for brain function …
kept up with this trend, especially cognitive health. Among nutrients for brain function …
Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance
J Yu, X Gao, L Zhang, H Shi, Y Yan, Y Han, C Wu… - Scientific Reports, 2024 - nature.com
Magnolol is a naturally occurring polyphenolic compound in many edible plants, which has
various biological effects including anti-aging and alleviating neurodegenerative diseases …
various biological effects including anti-aging and alleviating neurodegenerative diseases …
Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity
The dynamicity of the mitochondrial network is crucial for meeting the ever‐changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …
Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension
Y Song, D Liu, J Xie, J Xie, Y Chen, X Chen, X Hu… - Food & Function, 2024 - pubs.rsc.org
In this study, it was found that epigallocatechin-3-gallate (EGCG) could extend the lifespan
of Caenorhabditis elegans (C. elegans) induced by 100 μM acrolein (ACR) at all test …
of Caenorhabditis elegans (C. elegans) induced by 100 μM acrolein (ACR) at all test …
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the …
Worldwide the aging population continues to increase, so the concept of healthy longevity
medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits …
medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits …
[HTML][HTML] Purple pitanga extract and loaded liposomes effects in a tumorous Caenorhabditis elegans model
FS de Oliveira Pereira, GP Viçozzi, MEO Souza… - Journal of Agriculture …, 2024 - Elsevier
Abstract The Purple Pitanga Extract (PPE) demonstrated apoptotic and anti-cancer effects in
previous studies with cells. Therefore, the investigation of specific pathways involved in the …
previous studies with cells. Therefore, the investigation of specific pathways involved in the …
Decoding lifespan secrets: the role of the gonad in Caenorhabditis elegans aging
A Pires da Silva, R Kelleher, L Reynoldson - Frontiers in Aging, 2024 - frontiersin.org
The gonad has become a central organ for understanding aging in C. elegans, as removing
the proliferating stem cells in the germline results in significant lifespan extension. Similarly …
the proliferating stem cells in the germline results in significant lifespan extension. Similarly …
Senotherapy, cancer, and aging
L Balducci, C Falandry, S Monfardini - Journal of Geriatric Oncology, 2023 - Elsevier
Introduction We aimed to highlight the effects of senotherapy on the prevention and
treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent …
treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent …