Hormesis determines lifespan

EJ Calabrese, M Nascarella, P Pressman… - Ageing Research …, 2024 - Elsevier
This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

Insulin and aging–a disappointing relationship

H Kolb, K Kempf, S Martin - Frontiers in Endocrinology, 2023 - frontiersin.org
Experimental studies in animal models of aging such as nematodes, fruit flies or mice have
observed that decreased levels of insulin or insulin signaling promotes longevity. In humans …

Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans

I Mora, A Pérez-Santamaria, J Tortajada-Pérez… - Cells, 2023 - mdpi.com
The human lifespan has increased over the past century; however, healthspans have not
kept up with this trend, especially cognitive health. Among nutrients for brain function …

Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance

J Yu, X Gao, L Zhang, H Shi, Y Yan, Y Han, C Wu… - Scientific Reports, 2024 - nature.com
Magnolol is a naturally occurring polyphenolic compound in many edible plants, which has
various biological effects including anti-aging and alleviating neurodegenerative diseases …

Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity

A Traa, A Keil, A AlOkda, S Jacob‐Tomas… - Aging …, 2024 - Wiley Online Library
The dynamicity of the mitochondrial network is crucial for meeting the ever‐changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …

Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension

Y Song, D Liu, J Xie, J Xie, Y Chen, X Chen, X Hu… - Food & Function, 2024 - pubs.rsc.org
In this study, it was found that epigallocatechin-3-gallate (EGCG) could extend the lifespan
of Caenorhabditis elegans (C. elegans) induced by 100 μM acrolein (ACR) at all test …

Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the …

D Golubev, E Platonova, N Zemskaya, O Shevchenko… - Biogerontology, 2023 - Springer
Worldwide the aging population continues to increase, so the concept of healthy longevity
medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits …

[HTML][HTML] Purple pitanga extract and loaded liposomes effects in a tumorous Caenorhabditis elegans model

FS de Oliveira Pereira, GP Viçozzi, MEO Souza… - Journal of Agriculture …, 2024 - Elsevier
Abstract The Purple Pitanga Extract (PPE) demonstrated apoptotic and anti-cancer effects in
previous studies with cells. Therefore, the investigation of specific pathways involved in the …

Decoding lifespan secrets: the role of the gonad in Caenorhabditis elegans aging

A Pires da Silva, R Kelleher, L Reynoldson - Frontiers in Aging, 2024 - frontiersin.org
The gonad has become a central organ for understanding aging in C. elegans, as removing
the proliferating stem cells in the germline results in significant lifespan extension. Similarly …

Senotherapy, cancer, and aging

L Balducci, C Falandry, S Monfardini - Journal of Geriatric Oncology, 2023 - Elsevier
Introduction We aimed to highlight the effects of senotherapy on the prevention and
treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent …