[HTML][HTML] Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

S Nakahata, D Enriquez-Vera, MI Jahan, K Sugata… - Biomolecules, 2023 - mdpi.com
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL).
HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host …

[HTML][HTML] The roles of FHL3 in cancer

Z Huang, C Yu, L Yu, H Shu, X Zhu - Frontiers in Oncology, 2022 - frontiersin.org
The four and a half LIM domain protein 3, also named the LIM-protein FHL3, belongs to the
LIM-only family. Based on the special structure of LIM-only proteins, FHL3 can perform …

[HTML][HTML] Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival

R Hleihel, H Skayneh, H de Thé, O Hermine… - Blood Cancer …, 2023 - nature.com
Adult T cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic
infection with human T cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax …

[HTML][HTML] Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell …

H El Hajj, A Bazarbachi - Frontiers in Immunology, 2022 - frontiersin.org
The Human T-cell Leukemia virus type 1 (HTLV-1) causes an array of pathologies, the most
aggressive of which is adult T-cell leukemia (ATL), a fatal blood malignancy with dismal …

[HTML][HTML] Oncoviruses: how do they hijack their host and current treatment regimes

K Ahmed, S Jha - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Viruses have the ability to modulate the cellular machinery of their host to ensure their
survival. While humans encounter numerous viruses daily, only a select few can lead to …

The unique activity of saponin: Induction of cytotoxicity in HTLV-1 infected cells

W Shida, Y Tahara, S Morikawa, K Monde… - Bioorganic & Medicinal …, 2023 - Elsevier
Infection with the retrovirus human T-cell leukemia virus type 1 (HTLV-1) sometimes causes
diseases that are difficult to cure. To find anti-HTLV-1 natural compounds, we opted to …

Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo

S Ahmadi Ghezeldasht, HR Bidkhori, R Miri… - Journal of …, 2023 - Springer
There is an urgent need to find an effective therapy for life-threatening HTLV-1-associated
diseases. Bitter melon (Momordica charantia) is considered a traditional herb with antiviral …

[HTML][HTML] Prediction of the adult T-cell leukemia inhibitory activity of blueberry leaves/stems using direct-injection electron ionization-mass spectrometry metabolomics

H Kai, Y Okada, Y Goto, T Nakayama, K Sugamoto… - Plants, 2022 - mdpi.com
Although Vaccinium virgatum Aiton leaves and stems inhibit adult T-cell leukemia (ATL)
cells, leaves and stems can differ between individual plants and by time and location. In this …

Pivotal role of dihydroorotate dehydrogenase as a therapeutic target in adult T‐cell leukemia

C Ishikawa, N Mori - European Journal of Haematology, 2024 - Wiley Online Library
Objectives We aimed to determine the role of dihydroorotate dehydrogenase (DHODH) in
pathogenesis of adult T‐cell leukemia (ATL) caused by human T‐cell leukemia virus type 1 …

Inhibitory effect of a neddylation blockade on HTLV-1-infected T cells via modulation of NF-κB, AP-1, and Akt signaling

C Ishikawa, N Mori - Leukemia & Lymphoma, 2024 - Taylor & Francis
Adult T-cell leukemia (ATL), caused by HTLV-1, is the most lethal hematological malignancy.
NEDD8-activating enzyme (NAE) is a component of the NEDD8 conjunction pathway that …