Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

Alzheimer's disease (AD) is an irreversible brain disorder associated with slow, progressive
loss of brain functions mostly in older people. The disease processes start years before the …

Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have
been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with …

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …