Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

In vitro pharmacological profiling is increasingly being used earlier in the drug discovery
process to identify undesirable off-target activity profiles that could hinder or halt the …

Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC)
and cannabidiol (CBD), are receiving growing attention in both the media and the scientific …

Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

Dexmedetomidine is a new generation highly selective α2-adrenergic receptor (α2-AR)
agonist that is associated with sedative and analgesic sparing effects, reduced delirium and …

Introduction Acute kidney injury following surgery incurs significant mortality with no proven
preventative therapy. We investigated whether the α 2 adrenoceptor agonist …

Dexmedetomidine is an alpha 2 adrenergic receptor agonist, even ten times more selective
than clonidine. It is a very versatile drug in anaesthesia practice, finding place in increasing …

BACKGROUND: Clonidine, an α-2 adrenoceptor agonist, is a common adjunct in both
central and peripheral blocks. Dexmedetomidine, a more selective α-2 adrenoceptor …

Dexmedetomidine offers beneficial pharmacological properties, providing dose-dependent
sedation, analgesia, sympatholysis and anxiolysis without relevant respiratory depression …

This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …