Hematological toxicity is the most common adverse event after chimeric antigen receptor
(CAR) T-cell therapy. Cytopenias can be profound and long-lasting and can predispose for …

In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Background CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) represents a
promising treatment modality for an increasing number of B-cell malignancies. However …

The human microbiota is a unique set of microorganisms colonizing the human body and
evolving within it from the very beginning. Acting as an insider, the microbiota provides …

Simple Summary CAR-T cell therapy has recently revolutionized the field of cancer
therapeutics, especially for hematological malignancies, and is also evolving as an …

Gut microbiota is essential for maintaining local and systemic immune homeostasis in the
presence of bacterial challenges. It has been demonstrated that microbiota play contrasting …

In the last decade, metagenomic studies have shown the key role of the gut microbiome in
maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can …

Immunotherapy has emerged as a robust approach against cancer, yet its efficacy has
varied among individuals, accompanied by the occurrence of immune-related adverse …

Gut microbiota represents a hidden treasure vault encompassing trillions of microorganisms
that inhabit the intestinal epithelial barrier of the host. In the past decade, numerous in-vitro …

New concepts and drugs have revolutionized medical treatment for cancers. These drugs,
which are very expensive and usually well tolerated, have dramatically improved cancer …