Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-
19, a pandemic disease. This disease is characterized by acute respiratory distress …

Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is
involved in microbicidal activity. NE is an important factor promoting inflammation, has …

Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 …

This review describes targeting neutrophils as a potential therapeutic strategy for acute
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …

The COVID‐19 pandemic extended all around the world causing millions of deaths. In
addition to acute respiratory distress syndrome, many patients with severe COVID‐19 …

This article summarizes the effects of sivelestat on ALI/ARDS or ARDS with coagulopathy,
both of which are frequently seen in patients with COVID-19. The emergence of the novel …

The precise interaction between the immune system and severe acute respiratory syndrome
coronavirus 2 (SARS‑CoV‑2) is critical in deciphering the pathogenesis of coronavirus …

Elastases are a broad group of enzymes involved in the lysis of elastin, the main component
of elastic fibres. They are produced and released in the human body, mainly by neutrophils …

COVID-19 can cause acute respiratory distress syndrome, leading to death in many
individuals. Evidence of a deleterious role of the innate immune system is accumulating, but …