DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative
super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

In Escherichia coli, the miniF plasmid CcdB protein is responsible for cell death when its
action is not prevented by polypeptide CcdA. We report the isolation, localization …

Synopsis Levofloxacin, an oral fluoroquinolone antibacterial agent, is the optical S-(-) isomer
of ofloxacin. In vitro it is generally twice as potent as ofloxacin. Levofloxacin is active against …

Camptothecin, a cytotoxic antitumor compound, has been shown toproduce protein-linked
DNA breaks mediated bymammalian topoisomerase I. We have investigated the mechanism …

The crystal structure of an N-terminal fragment of the Escherichia coli DNA gyrase B protein,
com-plexed with a nonhn/drolysable ATP analogue, has been solved at 2.5 Å resolution. It …

This text offers an up-to-date review of the field of cancer chemotherapy, including some of
the new approaches to biological treatments of cancer and potential targets for new drug …

INTRODUCTION The faithful replication and segregation of chromosomes as part of the cell
division cycle requires that topological changes be imposed upon cellular DNA …

Natural and synthetic cyclopropanes bearing simple functionalities are endowed with a
large spectrum of biological properties ranging from enzyme inhibitions to insecticidal …

The mechanism of inhibition of eukaryotic DNA topoisomerase II [DNA topoisomerase (ATP-
hydrolyzing), EC 5.99. 1.3] by a member of the bisdioxopiperazine family of anticancer …