Bile acids are important physiological agents for intestinal nutrient absorption and biliary
secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO)
have recently been linked to cardiovascular disease (CVD) risk. Here, we performed …

Recent evidence, including massive gene-expression analysis and a wide-variety of other
multi-omics approaches, demonstrates an interplay between gut microbiota and the …

Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut
microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated …

Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL
particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is …

ABCG5 (G5) and ABCG8 (G8) form a sterol transporter that acts in liver and intestine to
prevent accumulation of dietary sterols. Mutations in either G5 or G8 cause sitosterolemia, a …

Lipid metabolism deregulation constitutes the pathogenic basis for the development of
atherosclerosis and justifies a high incidence of cardiovascular-related morbidity and …

Quercetin is a dietary flavonoid compound extracted from various plants, such as apple and
onions. Previous studies have revealed its anti-inflammatory, anti-cancer, antioxidant and …

Whereas LDL-derived cholesterol accumulates in atherosclerotic lesions, HDL particles are
thought to facilitate removal of cholesterol from the lesions back to the liver thereby …