Abstract As of May 1, 2017, 74 antibody-based molecules have been approved by a
regulatory authority in a major market. Additionally, there are 70 and 575 antibody-based …

One of the first difficulties in developing monoclonal antibody therapeutics was the
recognition that human anti-mouse antibody (HAMA) response limited the administration of …

A new system for lineage ablation is based on transgenic expression of a diphtheria toxin
receptor (DTR) in mouse cells and application of diphtheria toxin (DT). To streamline this …

The immune response depends on the binding of opsonized antigens to cellular Fc
receptors and the subsequent initiation of various cellular effector functions of the immune …

This study investigated the efficacy, safety, and clinical benefit of alemtuzumab (Campath-
1H) for patients with relapsed or refractory B-cell chronic lymphocytic leukemia exposed to …

Purpose The antiepidermal growth factor receptor antibody cetuximab shows activity in
irinotecan-refractory metastatic colorectal cancer (mCRC), mainly in wild-type KRAS tumors …

2004-11-10 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …

Subclasses of human IgG have a range of activity levels with different effector systems but
each triggers at least one mechanism of cell destruction. We are aiming to engineer non …

Abstract Background Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are novel agents
for type 2 diabetes treatment, offering glucose‐dependent insulinotropic effects, reduced …

2005-09-29 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYES, ROBERT …