The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

In tumours, hypoxia—a condition in which the demand for oxygen is higher than its
availability—is well known to be associated with reduced sensitivity to radiotherapy and …

The biological and clinical heterogeneity of neuroblastoma (NB) demands novel biomarkers
and therapeutic targets in order to drive the most appropriate treatment for each patient …

Carbonic anhydrase IX (CAIX) is a transmembrane enzyme that regulates pH in hypoxic
tumors and promotes tumor cell survival. Its expression is associated with the occurrence of …

Neuroblastoma is a rare disease. Rare are also the possibilities to test new therapeutic
options for neuroblastoma in clinical trials. Despite the constant need to improve therapy …

The water channel aquaporin 1 (AQP1) has been implicated in tumor progression and
metastasis. It is hypothesized that AQP1 expression can facilitate the transmembrane water …

Neuroblastoma (NB) is a rare type of cancer but frequently occurred in children. However, it
is still unclear whether circular RNAs (circRNAs) play key roles in NB tumorigenesis or …

Chronic mountain sickness (CMS) is a progressive incapacitating syndrome induced by
lifelong exposure to hypoxia. In the present study, proteomic analysis was used to identify …

Carbonic anhydrase IX (CAIX) is an enzyme expressed on the surface of cells in hypoxic
tumors. It plays a role in regulation of tumor pH and promotes thus tumor cell survival and …

Glioblastomas (GBMs), the most common and lethal primary brain tumor, show inherent
infiltrative nature and high molecular heterogeneity that make complete surgical resection …