Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …

Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …

Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have
additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an …

Cutaneous adverse drug reactions are unpredictable and include various different skin
conditions of varying degrees of severity. The most concerning are usually referred to as …

Background Toxic epidermal necrolysis (TEN) is a severe and potentially lethal drug
reaction for which no standard treatment is available. Objective To describe a case series of …

Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-
threatening diseases; however, it is hard to estimate their incidence due to the rarity of these …

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe
cutaneous drug reaction characterized by fever, lymphadenopathy, hematologic …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the leading cause of hypersensitivity
drug reactions. The different chemical structures, cyclooxygenase 1 (COX-1) and/or COX-2 …

Background & Aims Rare cases of azithromycin-induced hepatotoxicity have been reported,
with variable clinical and histologic features. We characterized clinical features and …

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of acute,
delayed-type hypersensitivity reactions that affect the skin and the mucous membranes …