Targeting ferroptosis opens new avenues for the development of novel therapeutics
S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
The cell biology of ferroptosis
SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
Lipid droplets and cellular lipid flux
AJ Mathiowetz, JA Olzmann - Nature Cell Biology, 2024 - nature.com
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …
Lipid quality control and ferroptosis: from concept to mechanism
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the
system xc− cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione …
system xc− cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione …
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
How cells coordinate cell cycling with cell survival and death remains incompletely
understood. Here, we show that cell cycle arrest has a potent suppressive effect on …
understood. Here, we show that cell cycle arrest has a potent suppressive effect on …
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs
C Wang, M Zhang, Y Liu, D Cui, L Gao… - Journal of Experimental & …, 2023 - Springer
Background Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How
circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains …
circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains …
Exploiting ferroptosis vulnerabilities in cancer
T Nakamura, M Conrad - Nature Cell Biology, 2024 - nature.com
Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This
process has been increasingly contemplated as a new target for cancer therapy because of …
process has been increasingly contemplated as a new target for cancer therapy because of …
Metal-phenolic nanocatalyst rewires metabolic vulnerability for catalytically amplified ferroptosis
Ferroptosis is associated with excessive lipid peroxidation (LPO) accumulation, followed by
membrane fragmentation. Although lipid metabolism is essential for regulating ferroptosis …
membrane fragmentation. Although lipid metabolism is essential for regulating ferroptosis …
Effect of radiotherapy on head and neck cancer tissues in patients receiving radiotherapy: a bioinformatics analysis-based study
Z Guan, J Liu, L Zheng - Scientific Reports, 2024 - nature.com
Radiotherapy is pivotal in treating head and neck cancers including nasopharyngeal,
tongue, hypopharyngeal, larynx, maxillary sinus, parotid gland, and oral cancers. It holds the …
tongue, hypopharyngeal, larynx, maxillary sinus, parotid gland, and oral cancers. It holds the …