Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

Orosomucoid (ORM) is an acute-phase protein that belongs to the immunocalin subfamily, a
group of small-molecule-binding proteins with immunomodulatory functions. Little is known …

Astrocytes are known to play critical roles in central nervous system development,
homeostasis, and response to injury. In addition to well-defined functions in synaptic …

Epidemiological studies have observed an association between pesticide exposure and the
development of Parkinson's disease, but have not established causality. The concept of an …

Background Astrocyte-mediated neuroinflammation plays a critical role in ischemic stroke-
induced secondary cerebral injury. Previous studies have suggested that the dopamine D2 …

Alzheimer's disease is a neurodegenerative disease characterized by deposition of
extracellular amyloid‐β, intracellular neurofibrillary tangles, and loss of cortical neurons …

Unresolved inflammation is a significant predictor for developing chronic pain, and targeting
the mechanisms underlying inflammation offers opportunities for therapeutic intervention …

Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases which
occur in aged people worldwide. Given that a sequence of cellular and molecular …