Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

P Singh, KB Marcu, MB Goldring… - Annals of the New York …, 2019 - Wiley Online Library
Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Exosomes and stem cells in degenerative disease diagnosis and therapy

YH Chang, KC Wu, HJ Harn, SZ Lin… - Cell …, 2018 - journals.sagepub.com
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's
disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction …

[HTML][HTML] MicroRNA‑93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF‑κB signaling pathway

Y Ding, L Wang, Q Zhao, Z Wu… - … journal of molecular …, 2019 - spandidos-publications.com
Osteoarthritis (OA) is a serious disease of the articular cartilage, and inflammation has been
implicated in its pathogenesis. Previously, microRNAs (miRNAs) have been proposed as …

Role of MicroRNA, LncRNA, and exosomes in the progression of osteoarthritis: a review of recent literature

F Xie, Y Liu, X Chen, Q Li, J Zhong, B Dai… - Orthopaedic …, 2020 - Wiley Online Library
Osteoarthritis (OA) is a common clinical degenerative disease characterized by the
destruction of articular cartilage, which has an increasing impact on people's lives and social …

Signature of circulating microRNAs in osteoarthritis

C Beyer, A Zampetaki, NY Lin, A Kleyer… - Annals of the …, 2015 - ard.bmj.com
Background Osteoarthritis is the most common form of arthritis and a major socioeconomic
burden. Our study is the first to explore the association between serum microRNA levels and …

The microRNA-29 family in cartilage homeostasis and osteoarthritis

LTT Le, TE Swingler, N Crowe, TL Vincent… - Journal of molecular …, 2016 - Springer
MicroRNAs have been shown to function in cartilage development and homeostasis, as well
as in progression of osteoarthritis. The objective of the current study was to identify …

Chondrocyte hypertrophy in skeletal development, growth, and disease

MMG Sun, F Beier - Birth Defects Research Part C: Embryo …, 2014 - Wiley Online Library
Most of our bones form through the process of endochondral ossification, which is tightly
regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the …

Baicalin protects human OA chondrocytes against IL-1β-induced apoptosis and ECM degradation by activating autophagy via MiR-766-3p/AIFM1 Axis

Z Li, J Cheng, J Liu - Drug Design, Development and Therapy, 2020 - Taylor & Francis
Background Osteoarthritis (OA) is one of the most prevalent and degenerative diseases with
complicated pathology including articular cartilage degradation, subchondral sclerosis and …

[HTML][HTML] Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease?

LN Reynard - Seminars in Cell & Developmental Biology, 2017 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Emerging roles for long noncoding RNAs in skeletal biology and disease

NPT Huynh, BA Anderson, F Guilak… - Connective tissue …, 2017 - Taylor & Francis
Normal skeletal development requires tight coordination of transcriptional networks,
signaling pathways, and biomechanical cues, and many of these pathways are dysregulated …